期刊
CANCER LETTERS
卷 494, 期 -, 页码 73-83出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.08.028
关键词
Endoplasmic reticulum; IRE1; Glioblastoma; Unfolded Protein Response
类别
资金
- French National Cancer Institute (INCa)
- Fondation pour la recherche Medicale (FRM
- equipe labellisee 2018)
- EU [H2020 MSCA ITN-675448, MSCA RISE-734749]
- Science Foundation Ireland (SFI)
- European Regional Development Fund [13/RC/2073]
Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for success in finding novel improved therapeutic options for such dismal disease partly lies in the lack of a relevant animal model that accurately recapitulates patient disease and standard of care. In the present study, we have developed an immunocompetent GBM model that includes tumor surgery and a radio/chemotherapy regimen resembling the Stupp protocol and we have used this model to test the impact of the pharmacological inhibition of the endoplasmic reticulum (ER) stress sensor IRE1, on treatment efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据