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S. Floor et al.
ONCOGENE (2011)
MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
Ling-Zhi Liu et al.
PLOS ONE (2011)
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
Renaud Le Floch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Epithelial-Mesenchymal Transition in tumor microenvironment
Yingying Jing et al.
CELL AND BIOSCIENCE (2011)
Quiescent, Slow-Cycling StemCell Populations in Cancer: A Review of the Evidence and Discussion of Significance
Nathan Moore et al.
JOURNAL OF ONCOLOGY (2011)
Targeting hypoxia in cancer therapy
William R. Wilson et al.
NATURE REVIEWS CANCER (2011)
Regulation of cancer cell metabolism
Rob A. Cairns et al.
NATURE REVIEWS CANCER (2011)
Dysregulated pH: a perfect storm for cancer progression
Bradley A. Webb et al.
NATURE REVIEWS CANCER (2011)
microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity
J. Zhang et al.
BRITISH JOURNAL OF CANCER (2010)
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Andrew L. Doedens et al.
CANCER RESEARCH (2010)
VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop
Oscar Gonzalez-Moreno et al.
EXPERIMENTAL CELL RESEARCH (2010)
An inhibitory effect of miR-22 on cell migration and invasion in ovarian cancer
Jun Li et al.
GYNECOLOGIC ONCOLOGY (2010)
Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination
Einar K. Rofstad et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia INSIGHTS INTO CELLULAR TRANSFORMATION PROCESSES MEDIATED BY HIF-1
Ruth Schietke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
Johanna Chiche et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
miR-20b Modulates VEGF Expression by Targeting HIF-1α and STAT3 in MCF-7 Breast Cancer Cells
Sandra Cascio et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2010)
Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
Hongxia Z. Imtiyaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
Mitomu Kioi et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
Kasper M. A. Rouschop et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
Cesar A. Corzo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β
Paul Cao et al.
MOLECULAR CANCER (2010)
TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
B. Wang et al.
ONCOGENE (2010)
Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB
Nadine Rohwer et al.
PLOS ONE (2010)
Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells
Dejuan Kong et al.
PLOS ONE (2010)
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
Munekazu Yamakuchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
microRNA-181b targets MLK2 in HL-60 cells
Chen Hong et al.
SCIENCE CHINA-LIFE SCIENCES (2010)
Metabolic Modulation of Glioblastoma with Dichloroacetate
E. D. Michelakis et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Endothelial deletion of hypoxia-inducible factor-2α (HIF-2α) alters vascular function and tumor angiogenesis
Nicolas Skuli et al.
BLOOD (2009)
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN
Zvi G. Fridlender et al.
CANCER CELL (2009)
MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress
Meredith E. Crosby et al.
CANCER RESEARCH (2009)
Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells
Yiwei Li et al.
CANCER RESEARCH (2009)
Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
Yohei Shimono et al.
CELL (2009)
Development of HIF-1 inhibitors for cancer therapy
Barbara Onnis et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel
Changxing Liu et al.
JOURNAL OF CONTROLLED RELEASE (2009)
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
A. Soeda et al.
ONCOGENE (2009)
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
Jessica A. Bertout et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cancer Stem Cells, Hypoxia and Metastasis
Richard P. Hill et al.
SEMINARS IN RADIATION ONCOLOGY (2009)
Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche
Yoshiaki Kubota et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells
Lei Shi et al.
BRAIN RESEARCH (2008)
Effects of lentivirus-mediated HIF-1α knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells
J. Hao et al.
CANCER GENE THERAPY (2008)
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance
Norman Chan et al.
CANCER RESEARCH (2008)
A microRNA component of the hypoxic response
R. Kulshreshtha et al.
CELL DEATH AND DIFFERENTIATION (2008)
hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer
Carme Camps et al.
CLINICAL CANCER RESEARCH (2008)
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk et al.
EMBO REPORTS (2008)
miR-21 plays a pivotal role in gastric cancer pathogenesis and progression
Zhiyu Zhang et al.
LABORATORY INVESTIGATION (2008)
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
Qihong Huang et al.
NATURE CELL BIOLOGY (2008)
The role of oxygen availability in embryonic development and stem cell function
M. Celeste Simon et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
MicroRNA-373 induces expression of genes with complementary promoter sequences
Robert F. Place et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
Bikul Das et al.
STEM CELLS (2008)
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
Anthony G. Letai
NATURE REVIEWS CANCER (2008)
Hypoxia, DNA repair and genetic instability
Robert G. Bristow et al.
NATURE REVIEWS CANCER (2008)
Drug resistance and the solid tumor microenvironment
Olivier Tredan et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
Hypoxic suppression of the cell cycle gene CDC25A in tumor cells
Stefanie Hammer et al.
CELL CYCLE (2007)
HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity
John D. Gordan et al.
CANCER CELL (2007)
A microRNA signature of hypoxia
Ritu Kulshreshtha et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy
Subbareddy Maddika et al.
DRUG RESISTANCE UPDATES (2007)
A perivascular niche for brain tumor stem cells
Christopher Calabrese et al.
CANCER CELL (2007)
Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells
A. Di Sario et al.
DIGESTIVE AND LIVER DISEASE (2007)
MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia
Zhong Hua et al.
PLOS ONE (2006)
Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia:: Implications for anticancer therapies
Philippe Martinive et al.
CANCER RESEARCH (2006)
Polycomb silencers control cell fate, development and cancer
Anke Sparmann et al.
NATURE REVIEWS CANCER (2006)
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma:: HIF-2α promotes an aggressive phenotype
Linda Holmquist-Mengelbier et al.
CANCER CELL (2006)
被撤回的出版物: Lysyl oxidase is essential for hypoxia-induced metastasis (Retracted article. See vol. 579, pg. 456, 2020)
JT Erler et al.
NATURE (2006)
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
MS Ullah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
HIF-2α regulates Oct-4:: effects of hypoxia on stem cell function, embryonic development, and tumor growth
KL Covello et al.
GENES & DEVELOPMENT (2006)
A microRNA expression signature of human solid tumors defines cancer gene targets
S Volinia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Angiogenesis in life, disease and medicine
P Carmeliet
NATURE (2005)
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
RD Guzy et al.
CELL METABOLISM (2005)
Regulation of immune cells by local. tissue oxygen tension: Hif1 alpha and adenosine receptors
M Sitkovsky et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Hypoxia-mediated down-regulation of bid and bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
JT Erler et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Role of cell cycle in mediating sensitivity to radiotherapy
TM Pawlik et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction Of β2 integrin gene expression
TQ Kong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
H Burger et al.
BLOOD (2004)
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
P Krishnamurthy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
N Tang et al.
CANCER CELL (2004)
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
J Oliner et al.
CANCER CELL (2004)
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
C Murdoch et al.
BLOOD (2004)
HIF-1α induces cell cycle arrest by functionally counteracting Myc
M Koshiji et al.
EMBO JOURNAL (2004)
Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response
P Vaupel et al.
ONCOLOGIST (2004)
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
S Pennacchietti et al.
CANCER CELL (2003)
Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins
RP Czekay et al.
JOURNAL OF CELL BIOLOGY (2003)
Regulation of EMAP II by hypoxia
S Matschurat et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Increased radiosensitivity with chronic hypoxia in four human tumor cell lines
F Zölzer et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2002)
Hypoxia-induced pathways in breast cancer
TI Goonewardene et al.
MICROSCOPY RESEARCH AND TECHNIQUE (2002)
Cellular adaptation to hypoxia:: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
RH Wenger
FASEB JOURNAL (2002)
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
A Jögi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Activation of the HIF pathway in cancer
PH Maxwell et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)
Hypoxia inhibits G1/S transition through regulation of p27 expression
LB Gardner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Hypoxia and oxidative stress in breast cancer - Tumour hypoxia - therapeutic considerations
KJ Williams et al.
BREAST CANCER RESEARCH (2001)
The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression
G Berx et al.
BREAST CANCER RESEARCH (2001)
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
M Ohh et al.
NATURE CELL BIOLOGY (2000)
The plasminogen activation system in tumor growth, invasion, and metastasis
PA Andreasen et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2000)
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