4.4 Review

Vitamin K in CKD Bone Disorders

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Summary: Chronic kidney disease-mineral bone disorder (CKD-MBD) is closely linked to elevated cardiovascular morbidity and mortality in CKD patients. Emerging evidence suggests that pathways like canonical Wnt signaling are activated early in CKD and may play a role in the development of adynamic bone disease and vascular calcification. Studies show that the progression of vascular calcification parallels changes in bone mineral density and turnover, indicating shared pathways between bone and arterial mineralization. Further research is needed to identify new mediators involved in CKD-MBD pathogenesis and develop more effective therapeutic strategies.

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