Conjugate Addition of Acetal-Derived Benzyl Radicals Generated from Low-Valent Titanium-Mediated C-O Bond Cleavage

A new method for the generation of benzyl radicals from acetals via low-valent titanium-mediated homolytic C-O bond cleavage is presented. The low cost and availability of the developed titanium reagent enable efficient access to alpha-alkoxy carbon radical species via the developed reaction.

Automated summary

A new method involving low-valent titanium-mediated homolytic C-O bond cleavage for the generation of benzyl radicals from acetals is presented. The developed titanium reagent, which is low cost and easily accessible, enables efficient access to alpha-alkoxy carbon radical species via the reaction.