期刊
DERMATOLOGIC CLINICS
卷 34, 期 2, 页码 175-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2015.11.002
关键词
Isotretinoin; Acne; Dosing; Relapse; Adverse events; Mechanism
类别
Oral isotretinoin is unrivalled in efficacy and remission capability for treatment of acne. In addition to appropriate monitoring and continued vigilance for safety concerns, appropriate dosing to mitigate avoidable dose-dependent adverse effects is the responsibility of prescribers. Low-dose regimens are better tolerated and effective in inducing acne clearance. Although much progress has been made since the advent of isotretinoin, there remain many unanswered questions regarding optimization to maximize response while minimizing the potential for avoidable adverse events. The ongoing availability of isotretinoin is imperative to patients with acne, their caregivers, and physicians.
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