期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 192, 期 3, 页码 634-642出版社
WILEY
DOI: 10.1111/bjh.17242
关键词
sickle cell anaemia; vascular complications; microparticles; sub‐ Saharan Africa
类别
资金
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Agence National de la Recherche (ANR) [ANR-14-CE15-0018]
- Laboratory of Excellence GR-Ex [ANR-11-LABX0051]
- programme 'Investissements d'avenir' of the Agence National de la Recherche [ANR-11-IDEX-0005-02]
- Fondation Pierre Fabre
- Agence Nationale de la Recherche (ANR) [ANR-14-CE15-0018] Funding Source: Agence Nationale de la Recherche (ANR)
This study analyzed blood cell-derived microparticles in stable SCD patients living in sub-Saharan Africa, revealing associations between microparticles and complications such as retinopathy, priapism, and leg ulcers. Furthermore, the study suggests a weak relevance of the hyper-hemolysis versus hyper-viscous paradigm in Africa.
Although most individuals with sickle cell disease (SCD) live in sub-Saharan Africa, the natural history of the disease on this continent remains largely unknown. Intravascular haemolysis results in activation of circulating blood cells and release of microparticles (MPs) that exert pro-inflammatory effects and contribute to vascular damage. We designed a case-control study nested in the CADRE cohort (Coeur-Artere-DRepanocytose, clinical trials.gov identifier NCTO3114137) and based on extreme phenotypes, to analyse blood cell-derived MPs in 232 adult SS patients at steady state in Bamako and Dakar. Thirty-six healthy adult controls matched by age and sex were recruited in Bamako. The MPs concentrations were higher in SS patients compared to AA controls with a predominance of erythrocyte- and reticulocyte-derived MPs. These erythroid-derived MPs were significantly lower in patients with retinopathy (P = 0 center dot 022). Reticulocyte-derived MPs were significantly negatively and positively associated with a history of priapism (P = 0 center dot 020) and leg ulcers (P = 0 center dot 041) respectively. We describe for the first time the comparative patterns of plasma MPs in healthy subjects and patients with SCD living in sub-Saharan Africa and exhibiting various complications. Because our present results show no clear pattern of correlation between erythroid MPs and the classical hyper-haemolytic complications, we hypothesise a weak relevance of the hyper-haemolysis versus hyper-viscous paradigm in Africa.
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