4.7 Letter

Comment on Heterogeneity in PD-L1 expression in malignant peritoneal mesothelioma with systemic or intraperitoneal chemotherapy

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Article Oncology

Heterogeneity in PD-L1 expression in malignant peritoneal mesothelioma with systemic or intraperitoneal chemotherapy

Michael G. White et al.

Summary: PD-L1 expression in patients with malignant peritoneal mesothelioma is associated with germline and somatic mutations. Patients who had received prior chemotherapy showed varying levels of PD-L1 expression, with some exhibiting upregulation and others downregulation. The heterogeneity in PD-L1 expression before and after cytotoxic therapies may impact the effectiveness of immune checkpoint inhibition in this challenging disease.

BRITISH JOURNAL OF CANCER (2021)