期刊
BRAIN STRUCTURE & FUNCTION
卷 226, 期 1, 页码 195-205出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-020-02176-6
关键词
Ventromedial hypothalamus; Instinctive predator fear; Connectivity; Mapping; Marmoset; Nonhuman primate
资金
- Projekt DEAL
The study found that the ventromedial hypothalamus is involved in fear responses in primates, as demonstrated by flight reactions in marmoset monkeys when exposed to predators in laboratory conditions. Additionally, the anatomical connectivity of the medial hypothalamic defensive system in rodents and primates is highly conserved.
In rodents, innate and learned fear of predators depends on the medial hypothalamic defensive system, a conserved brain network that lies downstream of the amygdala and promotes avoidance via projections to the periaqueductal gray. Whether this network is involved in primate fear remains unknown. To address this, we provoked flight responses to a predator (moving snake) in the marmoset monkey under laboratory conditions. We combined c-Fos immunolabeling and anterograde/retrograde tracing to map the functional connectivity of the ventromedial hypothalamus, a core node in the medial hypothalamic defensive system. Our findings demonstrate that the ventromedial hypothalamus is recruited by predator exposure in primates and that anatomical connectivity of the rodent and primate medial hypothalamic defensive system are highly conserved.
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