期刊
BRAIN RESEARCH BULLETIN
卷 166, 期 -, 页码 172-184出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2020.11.005
关键词
Brain-derived neurotrophic factor; Pro-brain-derived neurotrophic factor; Proteolytic cleavage; Neuropsychiatric diseases; Neurodegenerative disorders
资金
- National Natural Science Foundation of China [82060823,31700897,31960178]
- Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province [2017FA045,2018FB0 53,2019FA007]
- Yunnan Innovation Team of Application Research on Traditional Chinese Medicine Theory of Disease Prevention [2017HC011]
- Yunnan Provincial University Key Laboratory of Aromatic Chinese Herb Research
BDNF is implicated in neuropsychiatric diseases and neurodegenerative diseases, with the conversion of proBDNF to mBDNF considered crucial for disease pathogenesis and potential therapeutic benefits. Proteases play a key role in this conversion process, both intracellularly and extracellularly.
Brain-derived neurotrophic factor (BDNF) is involved in pathophysiological mechanisms in neuropsychiatric diseases, including depression, anxiety, and schizophrenia (SZ), as well as neurodegenerative diseases like Parkinson's disease (PD) and Alzheimer's disease (AD). An imbalance or insufficient pro-brain-derived neumtrophic factor (proBDNF) transformation into mature BDNF (mBDNF) is potentially critical to the disease pathogenesis by impairing neuronal plasticity as suggested by results from many studies. Thus, promoting proBDNF transformation into mBDNF is therefore hypothesized as beneficial for the treatment of neuropsychiatric and neurodegenerative diseases. ProBDNF is proteolytically cleaved into the mBDNF by intracellular furin/ proprotein convertases and extracellular proteases (plasmin/matrix metallopeptidases). This article reviews the mechanisms of the conversion of proBDNF to mBDNF and the research status of intracellular/extracellular proteolytic proteases for neuropsychiatric and neurodegenerative disorders.
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