4.5 Article

Accelerated brain aging in chronic low back pain

期刊

BRAIN RESEARCH
卷 1755, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.brainres.2020.147263

关键词

Chronic low back pain; Aging; Machine learning; Structural neuroimaging

资金

  1. NIMH [T32MH019986, T32AG021885, T32AG055381]
  2. National Institutes of Health (NIDA, NCCAM) [R01AT007137]

向作者/读者索取更多资源

Chronic low back pain is associated with accelerated aging in the brain, leading to cognitive impairments. This study used machine-learning estimated brain age as a metric to assess morphometric changes in CLBP patients. The results indicated that CLBP individuals had a brain age closer to older individuals, with lower gray matter density in various brain regions, and a stronger association between brain age and aging, particularly in later life.
Chronic low back pain (CLBP) is a leading cause of disability and is associated with neurodegenerative changes in brain structure. These changes lead to impairments in cognitive function and are consistent with those seen in aging, suggesting an accelerated aging pattern. In this study we assessed this using machine-learning estimated brain age (BA) as a holistic metric of morphometric changes associated with aging. Structural imaging data from 31 non-depressed CLBP patients and 32 healthy controls from the Pain and Interoception Imaging Network were included. Using our previously developed algorithm, we estimated BA per individual based on grey matter density. We then conducted multivariable linear modeling for effects of group, chronological age, and their interaction on BA. We also performed two voxel-wise analyses comparing grey matter density between CLBP and control individuals and the association between gray matter density and BA. There was an interaction between CLBP and greater chronological age on BA such that the discrepancy in BA between healthy and CLBP individuals was greater for older individuals. In CLBP individuals, BA was not associated with sex, current level of pain, duration of CLBP, or mild to moderate depressive symptoms. CLBP individuals had lower cerebellar grey matter density compared to healthy individuals. Brain age was associated with lower gray matter density in numerous brain regions. CLBP was associated with greater BA, which was more profound in later life. BA as a holistic metric was sensitive to differences in gray matter density in numerous regions which eluded direct comparison between groups.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据