期刊
BRAIN IMAGING AND BEHAVIOR
卷 15, 期 5, 页码 2417-2425出版社
SPRINGER
DOI: 10.1007/s11682-020-00440-1
关键词
Traumatic brain injury; Concussion; Amyloid; PET; Aging; Neurodegenerative; Dementia
类别
资金
- UCSF ADRC [NIA P50AG023501, P30AG062422]
- NIH-NIA [R01 AG045611, R01(s) AG032289, AG048234, K23 AG058752, K23 AG061253, K99AG065501]
- Larry L. Hillblom Network Grant [2014-A-004-NET]
- NIH-NINDS [K23 NS095755]
- American Federation for Aging Research
- Global Brain Health Institute
- Larry L. Hillblom Fellowship [2018-A-025-FEL]
- Alzheimer's Association [AARF-16-443577]
- Robert W. Katzman Fellowship Training Grant through the American Academy of Neurology
- American Brain Foundation
- Alzheimer's Association
In clinically normal older adults, a history of mTBI is not associated with higher cortical A beta burden and does not interact with A beta burden to affect cognition. However, remote mTBI may be linked to a faster rate of A beta accumulation.
We investigated whether clinically normal older adults with remote, mild traumatic brain injury (mTBI) show evidence of higher cortical A beta burden. Our study included 134 clinically normal older adults (age 74.1 +/- 6.8 years, 59.7% female, 85.8% white) who underwent A beta positron emission tomography (A beta-PET) and who completed the Ohio State University Traumatic Brain Injury Identification questionnaire. We limited participants to those reporting injuries classified as mTBI. A subset (N = 30) underwent a second A beta-PET scan (mean 2.7 years later). We examined the effect of remote mTBI on A beta-PET burden, interactions between remote mTBI and age, sex, and APOE status, longitudinal A beta accumulation, and the interaction between remote mTBI and A beta burden on memory and executive functioning. Of 134 participants, 48 (36%) reported remote mTBI (0, N = 86; 1, N = 31, 2+, N = 17; mean 37 +/- 23 years since last mTBI). Effect size estimates were small to negligible for the association of remote mTBI with A beta burden (p = .94, eta(2) < 0.01), and for all interaction analyses. Longitudinally, we found a non-statistically significant association of those with remote mTBI (N = 11) having a faster rate of A beta accumulation (B = 0.01, p = .08) than those without (N = 19). There was no significant interaction between remote mTBI and A beta burden on cognition. In clinically normal older adults, history of mTBI is not associated with greater cortical A beta burden and does not interact with A beta burden to impact cognition. Longitudinal analyses suggest remote mTBI may be associated with more rapid cortical A beta accumulation. This finding warrants further study in larger and more diverse samples with well-characterized lifelong head trauma exposure.
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