期刊
BLOOD PURIFICATION
卷 50, 期 4-5, 页码 499-505出版社
KARGER
DOI: 10.1159/000512371
关键词
COVID-19; Acute respiratory distress syndrome; Acute kidney injury; Mortality; Risk factors
资金
- National Key Research and Development Project of the Ministry of Science and Technology, China [2018YFC1313700]
- Gaoyuan Project of Pudong Health and Family Planning Commission [PWYgy2018-6]
- Research Foundation of Shanghai Science and Technology Commission [18140904100]
This multicenter retrospective study found that nearly half of COVID-19 patients with ARDS experienced AKI during their hospital stay, and the coexistence of AKI significantly increased the mortality of these patients.
Background: Acute kidney injury (AKI) is associated with increased mortality in patients with acute respiratory distress syndrome (ARDS). However, the epidemiological features and outcomes of AKI among COVID-19 patients with ARDS are unknown. Methods: We retrospectively recruited consecutive adult COVID-19 patients who were diagnosed with ARDS according to Berlin definition from 13 designated intensive care units in the city of Wuhan, China. Potential risk factors of AKI as well as the relation between AKI and in-hospital mortality were investigated. Results: A total of 275 COVID-19 patients with ARDS were included in the study, and 49.5% of them developed AKI during their hospital stay. In comparison with patients without AKI, patients who developed AKI were older, tended to have chronic kidney disease, had higher Sepsis-Related Organ Failure Assessment score on day 1, and were more likely to receive invasive ventilation and develop acute organ dysfunction. Multivariate analysis showed that age, history of chronic kidney disease, neutrophil-to-lymphocyte ratio, and albumin level were independently associated with the occurrence of AKI. Importantly, increasing AKI severity was associated with increased in-hospital mortality when adjusted for other potential variables: odds ratio of stage 1 = 5.374 (95% CI: 2.147-13.452; p < 0.001), stage 2 = 6.216 (95% CI: 2.011-19.210; p = 0.002), and stage 3 = 34.033 (95% CI: 9.723-119.129; p < 0.001). Conclusion: In this multicenter retrospective study, we found that nearly half of COVID-19 patients with ARDS experienced AKI during their hospital stay. The coexistence of AKI significantly increased the mortality of these patients.
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