期刊
BLOOD COAGULATION & FIBRINOLYSIS
卷 32, 期 4, 页码 237-247出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MBC.0000000000001011
关键词
biocompatibility; heparin; immobilization
类别
Blood contacting materials are crucial for biocompatibility, with heparin immobilization being a promising method to improve performance and reduce thrombus formation. Different methods of heparin immobilization and intermediates can affect the material's biocompatibility and stability.
Blood contacting materials are concerned with biocompatibility including thrombus formation, decrease blood coagulation time, hematology, activation of complement system, platelet aggression. Interestingly, recent research suggests that biocompatibility is increasing by incorporating various materials including heparin using different methods. Basic of heparin including uses and complications was mentioned, in which burst release of heparin is major issue. To minimize the problem of biocompatibility and unpredictable heparin release, present review article potentially reviews the reported work and investigates the various immobilization methods of heparin onto biomaterials, such as polymers, metals, and alloys. Detailed explanation of different immobilization methods through different intermediates, activation, incubation method, plasma treatment, irradiations and other methods are also discussed, in which immobilization through intermediates is the most exploitable method. In addition to biocompatibility, other required properties of biomaterials like mechanical and corrosion resistance properties that increase by attachment of heparin are reviewed and discussed in this article.
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