期刊
BIOTECHNOLOGY LETTERS
卷 43, 期 4, 页码 767-779出版社
SPRINGER
DOI: 10.1007/s10529-020-03058-x
关键词
Gastric cancer; Circ_0081146; MiR-144; HMGB1
资金
- Shanghai Pudong Commission of Health and Family Planning [PWRd2016-12]
- Talents Training Program of Seventh People's Hospital of Shanghai University of TCM [XX2019-07]
The study reveals that circ_0081146 is upregulated in gastric cancer and acts as an oncogene by promoting cell growth, migration, and invasion through modulating the miR-144/HMGB1 axis.
Objectives Recent studies have revealed that circular RNA (circRNA) plays a pivotal role in cancer development. The study aimed to investigate the role of circ_0081146 in gastric cancer (GC). Results Circ_0081146 was upregulated in GC tissues and cells. Patients with high expression of circ_0081146 had a significantly reduced 5-year overall survival rate. Circ_0081146 knockdown restrained the growth, migration and invasion of GC cells in vitro as well as tumorigenesis in vivo. Circ_0081146 targeted miR-144 and HMGB1 was targeted by miR-144. Circ_0081146 was negatively correlated with miR-144 expression, while positively correlated with HMGB1 expression in GC tissues. Moreover, the inhibitory effect of circ_0081146 knockdown on the progression of GC cells were reversed by silencing miR-144 or HMGB1 overexpression. Mechanically, circ_0081146 increased HMGB1 expression by targeting miR-144. Conclusion Circ_0081146 functions as an oncogene in GC to promote cell growth, migration and invasion via modulating the miR-144/HMGB1 axis.
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