4.7 Article

Evaluation of imidazo[2,1-b]thiazole-based anticancer agents in one decade (2011-2020): Current status and future prospects

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BIOORGANIC & MEDICINAL CHEMISTRY
卷 29, 期 -, 页码 -

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2020.115897

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Anticancer; Antiproliferative; Imidazo[2,1-b]thiazole; Imidazothiazole; Kinase inhibitor; Tubulin

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This article reviewed the potential anticancer properties of imidazo[2,1-b]thiazole derivatives, focusing on their biological characteristics and structure-activity relationship (SAR). Reports published in the literature from 2011 to 2020 were the main focus of this review.
Several reports have highlighted imidazo[2,1-b]thiazole derivatives as potential antiproliferative agents. They act through kinase inhibition, tubulin inhibition, and other molecular mechanisms of action. In the current article, we reviewed the imidazo[2,1-b]thiazole-based compounds that were reported as anticancer agents. Their biological characteristics as well as structure-activity relationship (SAR) have been reviewed and evaluated. Our main focus was on the reports published in the literature from 2011 to 2020.

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