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Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Berislav V. Zlokovic
NATURE REVIEWS NEUROSCIENCE (2011)
MECHANISM OF NEUROPROTECTION OF MELATONIN AGAINST BETA-AMYLOID NEUROTOXICITY
M. Ionov et al.
NEUROSCIENCE (2011)
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
Nadia Nabil Haj-Yasein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology
Jun Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
Melatonin reduces hippocampal β-amyloid generation in rats exposed to chronic intermittent hypoxia
Kwong-Man Ng et al.
BRAIN RESEARCH (2010)
The RAGE Axis A Fundamental Mechanism Signaling Danger to the Vulnerable Vasculature
Shi Fang Yan et al.
CIRCULATION RESEARCH (2010)
Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease Implications for Aβ accumulation in AD brain
Joshua B. Owen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Statins and the Squalene Synthase Inhibitor Zaragozic Acid Stimulate the Non-Amyloidogenic Pathway of Amyloid-beta Protein Precursor Processing by Suppression of Cholesterol Synthesis
Elzbieta Kojro et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Melatonin Protects CD4+ T Cells from Activation-Induced Cell Death by Blocking NFAT-Mediated CD95 Ligand Upregulation
Alziana Moreno da Cunha Pedrosa et al.
JOURNAL OF IMMUNOLOGY (2010)
Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
Xu Wang et al.
MOLECULAR NEURODEGENERATION (2010)
Structure and function of the blood-brain barrier
N. Joan Abbott et al.
NEUROBIOLOGY OF DISEASE (2010)
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
Margarita L. Dubocovich et al.
PHARMACOLOGICAL REVIEWS (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons
Hyun Jin Cho et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide
Emilie Cerf et al.
BIOCHEMICAL JOURNAL (2009)
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein
Benjamin Harris et al.
BRAIN RESEARCH (2009)
Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin
Russel J. Reiter et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2009)
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
Frank Tippmann et al.
FASEB JOURNAL (2009)
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide
Diego Albani et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
Carl Julien et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)
Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats
Hung-Ming Chang et al.
JOURNAL OF PINEAL RESEARCH (2009)
Melatonin down-regulates HIF-1α expression through inhibition of protein translation in prostate cancer cells
Jong-Wook Park et al.
JOURNAL OF PINEAL RESEARCH (2009)
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Dong-Hyung Cho et al.
SCIENCE (2009)
The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer
Jessica Pruessmeyer et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2009)
Late Evening Brain Activation Patterns and Their Relation to the Internal Biological Time, Melatonin, and Homeostatic Sleep Debt
Tali Gorfine et al.
HUMAN BRAIN MAPPING (2009)
Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling
Hyun Jin Cho et al.
AGING CELL (2008)
Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression
Ana I. Duarte et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers
S. Otmani et al.
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2008)
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities - A randomized controlled trial
Rixt F. Riemersma-van der Lek et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2008)
Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease
Glenna A. Dowling et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2008)
Melatonin induces akt phosphorylation through melatonin receptor- and PI3K-dependent pathways in primary astrocytes
Pil-Jae Kong et al.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2008)
The blood-brain barrier in health and chronic neurodegenerative disorders
Berislav V. Zlokovic
NEURON (2008)
Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death
R. Resende et al.
NEUROSCIENCE (2008)
Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways
Seithikurippu R. Pandi-Perumal et al.
PROGRESS IN NEUROBIOLOGY (2008)
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of age sleep and next-day alertness outcomes
Alan G. Wade et al.
CURRENT MEDICAL RESEARCH AND OPINION (2007)
Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease
Ying-Hui Wu et al.
NEUROBIOLOGY OF AGING (2007)
Actigraphy in agitated patients with dementia - Monitoring treatment outcomes
R. Mahlberg et al.
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE (2007)
Sleep and sleep disturbances: biological basis and clinical implications
N. Zisapel
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Effect of melatonin on cholesterol absorption in rats
Saad Abdul-Rehman Hussain
JOURNAL OF PINEAL RESEARCH (2007)
The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
Egemen Savaskan et al.
CURRENT ALZHEIMER RESEARCH (2007)
Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin-releasing hormone
Ying-Hui Wu et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2006)
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
Xiulian Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Hypoxia and reoxygenation increased BACE1 mRNA and protein levels in human neuroblastoma SH-SY5Y cells
Sufang Xue et al.
NEUROSCIENCE LETTERS (2006)
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
Weiping Qin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Alzheimer's disease β-amyloid peptides are released in association with exosomes
Lawrence Rajendran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The transcription factor Yin Yang 1 is an activator of BACE1 expression
K Nowak et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Melatonin increases NMDA receptor subunits 2A and 2B concentrations in rat hippocampus
R Sutcu et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2006)
Control of APP processing and Aβ generation level by BACE1 enzymatic activity and transcription
Yu Li et al.
FASEB JOURNAL (2006)
Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ
M Sastre et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Transcriptional and translational regulation of BACE1 expression - Implications for Alzheimer's disease
Steffen Rossner et al.
PROGRESS IN NEUROBIOLOGY (2006)
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model
JR Cirrito et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and n1-acetyl-5-methoxykynuramine (AMK), in macrophages
JC Mayo et al.
JOURNAL OF NEUROIMMUNOLOGY (2005)
Genomic structure and functional characterization of the human ADAM10 promoter
C Prinzen et al.
FASEB JOURNAL (2005)
Effects of melatonin on wortmannin-induced tau hyperphosphorylation
YQ Deng et al.
ACTA PHARMACOLOGICA SINICA (2005)
The human pineal gland and melatonin in aging and Alzheimer's disease
YH Wu et al.
JOURNAL OF PINEAL RESEARCH (2005)
Direct effect of melatonin on Syrian hamster testes: Melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system
NB Frungieri et al.
ENDOCRINOLOGY (2005)
Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
E Savaskan et al.
JOURNAL OF PINEAL RESEARCH (2005)
Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity
SP Li et al.
JOURNAL OF PINEAL RESEARCH (2004)
Expression of membrane and nuclear melatonin receptors in mouse peripheral organs
L Naji et al.
LIFE SCIENCES (2004)
Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for antiapoptotic effects of melatonin
SA Andrabi et al.
FASEB JOURNAL (2004)
ApoE and clusterin cooperatively suppress Aβ levels and deposition:: Evidence that ApoE regulates extracellular Aβ metabolism in vivo
RB DeMattos et al.
NEURON (2004)
LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
R Deane et al.
NEURON (2004)
Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain
DL Wang et al.
JOURNAL OF PINEAL RESEARCH (2004)
mRNA expression of nuclear receptor RZR/RORα, melatonin membrane receptor MT1, and hydroxindole-O-methyltransferase in different populations of human immune cells
D Pozo et al.
JOURNAL OF PINEAL RESEARCH (2004)
Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease -: An open-label pilot study using actigraphy
R Mahlberg et al.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2004)
The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells
B Chetsawang et al.
NEUROSCIENCE LETTERS (2004)
Gene regulation and DNA damage in the ageing human brain
T Lu et al.
NATURE (2004)
Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1
MA Christensen et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum
G Escames et al.
JOURNAL OF NEUROENDOCRINOLOGY (2004)
Expression of genes coding melatonin and serotonin receptors in rodent skin
A Slominski et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2004)
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
V Matthews et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
YC Liou et al.
NATURE (2003)
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
E Matsubara et al.
JOURNAL OF NEUROCHEMISTRY (2003)
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
CJ Phiel et al.
NATURE (2003)
Calreticulin-melatonin -: An unexpected relationship
M Macías et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: Alterations in preclinical and clinical stages
YH Wu et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease
C Singer et al.
SLEEP (2003)
Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients
E Savaskan et al.
JOURNAL OF PINEAL RESEARCH (2002)
Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Aβ peptide
B Poeggeler et al.
BIOCHEMISTRY (2001)
Amyloid β secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease
M Cruts et al.
NEUROSCIENCE LETTERS (2001)
Interaction between synthetic amyloid-β-peptide (1-40) and its aggregation inhibitors studied by electrospray ionization mass spectrometry
Z Skribanek et al.
JOURNAL OF MASS SPECTROMETRY (2001)
Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure
JW Clemens et al.
LIFE SCIENCES (2001)
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
E Kojro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease
T Murphy et al.
NEUROREPORT (2001)
Identification of the melatonin-binding site MT3 as the quinone reductase 2
O Nosjean et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Melatonin for treatment of sundowning in elderly persons with dementia - a preliminary study
J Cohen-Mansfield et al.
ARCHIVES OF GERONTOLOGY AND GERIATRICS (2000)
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