期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 133, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.110857
关键词
Gut microbiota; Metabolic disease; Therapeutic mechanism; Traditional Chinese medicine
资金
- Young Elite Scientists Sponsorship Program by CAST [YESS20170034, 2018QNRC2-C10]
- National Natural Science Foundation of China [81904187, 81430097, 81803923]
- Capital Health Development Research Project [CD2020-4-4155]
- Special Project for Capital Health Development
- Outstanding Young Scientific and Technological Talents Program [ZZ13-YQ-026]
Traditional Chinese medicines have shown considerable effects in treating metabolic disorders by regulating gut microbiota, particularly by affecting glucose and lipid metabolism through modulating specific types of bacteria. The potential mechanisms include protection of the intestinal barrier function, modulation of metabolic endotoxemia and inflammatory responses, regulation of SCFAs, modulation of the gut-brain axis, and regulation of bile acid and tryptophan metabolism.
Metabolic diseases such as obesity, type 2 diabetes mellitus, and hyperlipidemia are associated with the dysfunction of gut microbiota. Traditional Chinese medicines (TCMs) have shown considerable effects in the treatment of metabolic disorders by regulating the gut microbiota. However, the underlying mechanisms are unclear. Studies have shown that TCMs significantly affect glucose and lipid metabolism by modulating the gut microbiota, particularly mucin-degrading bacteria, bacteria with anti-inflammatory properties, lipopolysaccharide- and short-chain fatty acid (SCFA)-producing bacteria, and bacteria with bile-salt hydrolase activity. In this review, we explored potential mechanisms by which TCM improved metabolic disorders via regulating gut microbiota composition and functional structure. In particular, we focused on the protection of the intestinal barrier function, modulation of metabolic endotoxemia and inflammatory responses, regulation of the effects of SCFAs, modulation of the gut-brain axis, and regulation of bile acid metabolism and tryptophan metabolism as therapeutic mechanisms of TCMs in metabolic diseases.
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