期刊
BIOMEDICAL MATERIALS
卷 16, 期 2, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1748-605X/abdc97
关键词
brain-delivery; nanocarriers; liposomes; polymers; inorganic particles; nanoparticles
资金
- international cooperative project of the National Key R&D Program of China [2017YFE0126900]
- Program of Shanghai Academic Research Leader [18XD1400500]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- ZJLab
This passage discusses various types of brain drug delivery systems, including the development of nanocarriers such as liposomes, polymeric nanoparticles, and their transportation mechanisms and characteristics.
Pharmacotherapies for brain disorders are generally faced with obstacles from the blood-brain barrier (BBB). There are a variety of drug delivery systems that have been put forward to cross or bypass the BBB with the access to the central nervous system. Brain drug delivery systems have benefited greatly from the development of nanocarriers, including lipids, polymers and inorganic materials. Consequently, various kinds of brain drug delivery nano-systems have been established, such as liposomes, polymeric nanoparticles (PNPs), nanomicelles, nanohydrogels, dendrimers, mesoporous silica nanoparticles and magnetic iron oxide nanoparticles. The characteristics of their carriers and preparations usually differ from each other, as well as their transportation mechanisms into intracerebral lesions. In this review, different types of brain drug delivery nanocarriers are classified and summarized, especially their significant achievements, to present several recommendations and directions for future strategies of cerebral delivery.
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