期刊
BIOMEDICAL MATERIALS
卷 16, 期 2, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1748-605X/abd2c8
关键词
extracellular vesicles; exosomes; nano; theranostics
资金
- National Natural Science Foundation of China [21874011]
Extracellular vesicles (EVs) are cell secretory components with long circulation, good biocompatibility, and ability to cross physiologic barriers. Engineering modification is needed to enhance their stability, biological activity, and lesion-targeting capacity. Future clinical applications of EVs face challenges of limited accumulation at lesion sites and compromised therapy efficiency.
Extracellular vesicles (EVs) are cell secretory native components with long-circulation, good biocompatibility, and physiologic barriers cross ability. EVs derived from different donor cells inherit varying characteristics and functions from their original cells and are favorable to serve as vectors for diagnosing and treating various diseases. However, EVs nanotheranostics are still in their infancy because of their limited accumulation at lesion sites and compromised therapy efficiency. Hence, engineering modification of EVs is usually needed to further enhance their stability, biological activity, and lesion-targeting capacity. Herein, we overview the characteristics of EVs from different sources, as well as the latest developments of surface engineering and cargo loading methods. We also focus especially on advances in EVs-based disease theranostics. At the end of the review, we predict the obstacles and prospects of the future clinical application of EVs.
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