期刊
BIOMATERIALS
卷 268, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120541
关键词
Amphiphilic nanobowls; Dual-drug delivery; Cancer cell-mediated therapeutic strategy; EPR-independent strategy diagnostics and prevention of metastases
资金
- National Natural Science Foundation of China [21573040, 21872024]
- Education Department of Jilin Province 13th Five-Year Science and Technology Research [JJKH20190270KJ, JJKH20190272KJ]
- Fundamental Research Funds for the Central Universities [2412018ZD009, 2412019FZ009]
- Jilin Provincial Research Foundation for Basic Research [20160519012JH, 20190303100SF]
- Jilin Provincial Key Laboratory of Advanced Energy Materials
This study explores a novel nanoparticle-based therapeutic strategy to prevent hepatocellular carcinoma metastasis by delivering drugs to metastatic cells, effectively suppressing primary tumor growth and metastases. The use of cancer cell-mediated anti-metastasis therapy provides direction in the field of anti-metastasis therapy.
Motivated by the self-seeding of the cancer cells, the EPR-independent nanoparticles (NPs)-based therapeutic strategy have been explored to prevent hepatocellular carcinoma metastasis in this paper, the mechanism of anti metastasis of the NPs was also evaluated. We firstly have established an aggressive whole-body spreading orthotopic LM3 tumour model closing to actual cases of human patients and the synthesized Trojan Horse-like amphiphilic nanobowls have been engineered with dual drugs with completely different pharmacokinetic profiles for cancer cell-mediated anti-metastasis therapy. These Trojan Horse-like nanobowls can serve as dual-drug delivery depots for site-specific pH/NIR dual-stimuli drug release with effectively suppressed primary tumor growth and metastases. Furthermore, the multi-mode UCL/MR/CT imaging is competent for providing comprehensive and valuable information for evaluating and adjusting the treatment. The employ of cancer cell mediated anti-metastasis therapeutic strategy delivering drugs into metastatic cells to defeat tumor metastases provides directions in the fields of anti-metastasis therapy.
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