期刊
BIOMATERIALS
卷 270, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.120680
关键词
Biomaterial; Tumor microenvironment; Pancreatic cancer; Combination therapy; Clinical transformation
资金
- National Natural Science Foundation of China [81972901, 52022095, 51873207, 51803006]
- Science and Technology Development Program of Jilin Province [20190304049YY, 20200404182YY]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2019230]
- Key Research and Development Program of Science and Technology Department of Sichuan Province [2019YFS0514]
- Science and Technology Project of Chengdu [2019-YF05-00784-SN]
Pancreatic cancer is a deadly malignancy worldwide due to its insidious symptoms, early metastasis, and poor responses to treatment. Researchers are focusing on the tumor microenvironment as a key factor in treatment effectiveness and prognosis. Biomaterials are being developed to target components of the TME to inhibit cancer growth and metastasis.
Pancreatic cancer (PC) is one kind of the most lethal malignancies worldwide, owing to its insidious symptoms, early metastases, and negative responses to current therapies. With an increasing understanding of pathology, the tumor microenvironment (TME) plays a significant role in ineffective treatment and poor prognosis of PC. Thus, a growing number of studies have focused on whether components of the TME could be effective targets for PC therapy. Biomaterials have been widely applied in cancer therapy, and numerous organic or inorganic biomaterials for TME regulation have been developed to inhibit the growth and metastasis of PC, as well as reverse therapeutic resistance. In this review, we discuss various biomaterials utilized to treat PC based on different components of the TME, including, but not limited to, extracellular matrix (ECM), abnormal tumor vascularization, and tumor-associated immune cells, as well as other unconventional therapeutic strategies. Besides, the perspectives on the underlying future of theranostic nanomedicines for PC therapy are also presented.
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