期刊
BIOMATERIALS
卷 265, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120392
关键词
Nanoparticles; Immune cells; Trans-endothalial migration; Chemokine receptor; Nanoparticle-induced bluntness in immune cell (NIBIC)
资金
- National Natural Science Foundation of China [12032007, 31971242, 31701275]
- Natural Science Foundation of Chongqing [cstc2019jcyj-zdxmX0028]
- Chongqing Municipal Education Commission, China [KYYJ202001]
- Fundamental Research Funds for Central Universities [2019CDYGZD008]
The large-scale utilization of nanotechnology relies heavily on public and consumer trust in its safety. Research on nanoparticle interaction with immune cells is crucial for safety assessment in nanomedicine. Studies have shown that immune cells can experience reduced sensitivity and delayed response after phagocytizing gold nanoparticles, leading to nanoparticle-induced bluntness in immune cells (NIBIC).
The large-scale utilization of nanotechnology depends on public and consumer confidence in the safety of this new technology. Studying the interaction of nanoparticles with immune cells plays a vital role in the safety assessment of nanomedicine. Although some researches have indicated that the immune cells undergo severe interfere after phagocytosis of nanoparticles, the impact on immune system of the whole body are still unclear. Here, we use immune cells labeled transgenic zebrafish to study the mechanisms of nanoparticles on zebrafish immune cells. We demonstrate that gold nanoparticles (Au NPs) phagocytized by immune cells can reduce and retard the sensitivity of immune response, resulting nanoparticle-induced bluntness in immune cell (NIBIC). RNA-seq and functional analysis reveal that NIBIC is mainly induced by the inhibiting expression of chemokine receptor 5 (CCR5). Furthermore, PVP-modified Au NPs can eliminate NIBIC by inhibiting the cell phagocytosis. Our results highlight the potential risk for Au NPs in vivo and further the understanding of the mechanism of the interaction between Au NPs and the immune response. We should consider this factor in future material design and pay more attention to the process of using nanomedicines on immune diseases.
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