期刊
BIOMATERIALS
卷 262, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120346
关键词
TME-Responsive nanoplatform; Multiple anti-tumor therapy; Oxygen self-supplied producer; Simultaneously enhanced dual T-1/T-2 MR imaging
资金
- National Natural Science Foundation of China [21671064]
- Science and Technology Planning Project of Hunan Province [2017RS3031]
- Scientific Research Fund of Hunan Provincial Education Department [19A329]
- Natural Science Foundation of Hunan Province [2019JJ10002]
- Furong Scholars Programme of Hunan Province
The development of multifunctional nanoplatform with combination of tumor microenvironment (TME)-responsive dual T-1/T-2 magnetic resonance (MR) imaging and synergistically self-enhanced photothermal/photodynamic/chemo-therapy is of significant importance for tumor theranostic, which still remains a great challenge. Herein, a novel hollow mesoporous double-shell Co9S8@MnO2 nanoplatform loaded with photodynamic agent of indocyanine green molecules (ICG) and chemotherapy drug of doxorubicin (DOX) was designed for TME responsive dual T-1/T-2 enhanced MR imaging and synergistically enhanced anti-tumor therapy. The designed nanoplatform with MnO2 shell can act as a TME-responsive oxygen self-supplied producer to alleviate tumor hypoxia and simultaneously improve photodynamic therapy (PDT) efficiency. Moreover, the TME-induced MnO2 dissolving and near-infrared (NIR) triggered photothermal nature from Co9S8 shell can further promote the tumor-targeted DOX release, leading to the synergistically improved anti-tumor efficacy. And the simultaneous enhancement in dual T-1/T-2 MR signal was achieved for highly specific tumor diagnosis. The in vivo and in vitro results confirmed that the designed TME-triggered nanoplatform with synergistic combination therapy presented good biocompatibility, and superior inhibition of tumor growth than monotherapy. This study provides the opportunities of designing intelligent TME-activated nanoplatform for highly specific tumor MR imaging and collaborative self-enhanced tumor therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据