期刊
BIOMATERIALS
卷 270, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.120678
关键词
Tumor vaccine; Memory CD8+T cell; Photothermal therapy; T cell metabolism; Metformin
资金
- National Nature Science Foundation of China [81973246]
- National Natural Science Foundation of China [82003667]
- China Postdoctoral Science Foundation [2020M671772]
- National Key R&D Program of China [2017YFE0102200]
- National special fund for major new drug development [2017ZX09201004015]
Effective tumor vaccine is crucial in boosting immune system to produce more memory T cells, which has great potential for cancer prevention and therapy.
Tumor vaccine inducing effective and perdurable antitumor immunity has a great potential for cancer prevention and therapy. The key indicator for a successful tumor vaccine is boosting the immune system to produce more memory T cells. Although many tumor vaccines have been designed, few of them involve in actively regulating immune memory CD8+T cells. Here a tumor vaccine vector (TA-Met@MS) by encapsulating tumor antigen (TA), metformin (Met) and Hollow gold nanospheres (HAuNS) into poly (lactic-co-glycolic acid) (PLGA) microspheres was presented. TA via the treatment of photothermal therapy (PTT) showed high immunogenicity and immune-adjuvant effectiveness. And NIR light-mediated photothermal effect can lead to a pulsed-release behavior of TA and Met from the microspheres. The released TA can regulate primary T cell expansion and contraction, and stimulate the production of effector T cells at the early immunization stage. The metabolic behavior of the cells is then intervened from glycolysis into fatty acids oxidation (FAO) through the activation of AMPK mediated by Met, which can enhance T cell survival and facilitate the differentiation of memory CD8+T cells. This study may present a valuable insight to design tumor vaccine for enhanced cancer prevention and therapy.
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