期刊
BIOMATERIALS
卷 268, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120555
关键词
Osteoarthritis; Cartilage ECM; Homeostasis regulation; Regenerative medicine
资金
- National Key R&D Program of China [2017YFA0104900]
- Natural Sciences Foundation of China [81630065]
Osteoarthritis (OA) is a leading cause of disability and socioeconomic loss globally, with current pharmacological treatments mainly palliative. Focus is shifting towards targeting cartilage extracellular matrix (ECM) destruction and abnormal homeostasis in OA for regenerative therapies, using potential biomarkers and preclinical studies to identify pathological stages.
Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide. However, the current pharmacological approaches used to treat OA are largely palliative. Being the hallmark of OA, the cartilage extracellular matrix (ECM) destruction and abnormal homeostasis is gaining more attention as a therapeutic target in cartilage regeneration. Moreover, during the progression of OA, the cartilage ECM shows significant pathological alternations, which can be promising biomarkers in identifying the pathological stages of OA. In this review, we summarize the role of abnormal ECM homeostasis in the joint cartilage during OA. Furthermore, we provide an update on the cartilage ECM derived biomarkers and regenerative medicine therapies targeting cartilage ECM which includes preclinical animal models study and clinical trials.y
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