Dendritic Macromolecular Architectures: Dendrimer-Based Polyion Complex Micelles

Polymeric micelles are nanoassemblies that are formed by spontaneous arrangement of amphiphilic block copolymers in aqueous solutions at critical micelle concentration (CMC). They represent an effective system for drug delivery of, for instance, poorly water-soluble anticancer drugs. Then, the development of polyion complexes (PICs) were emphasized. The morphology of these complexes depends on the topology of the polyelectrolytes used and the way they are assembled. For instance, ionic-hydrophilic block copolymers have been used for the preparation of PIC micelles. The main limitation in the use of PIC micelles is their potential instability during the self-assembly/disassembly processes, influenced by several parameters, such as polyelectrolyte concentration, deionization associated with pH, ionic strength due to salt medium effects, mixing ratio, and PIC partide cross-linking. To overcome these issues, the preparation of stable PIC micelles by increasing the rigidity of their dendritic architecture by the introduction of dendrimers and controlling their number within micelle scaffold was highlighted. In this original concise Review, we will describe the preparation, molecular characteristics, and pharmacological profile of these stable nanoassemblies.

Automated summary

Polymeric micelles are nanoassemblies formed by amphiphilic block copolymers in aqueous solutions, used for drug delivery. Polyion complexes (PICs) morphology depends on polyelectrolytes topology and assembly, with stability issues overcome by increasing dendritic architecture rigidity and controlling dendrimer quantity. This stable nanoassemblies' preparation, molecular characteristics, and pharmacological profile are highlighted.