期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 199, 期 10, 页码 3869-3885出版社
SPRINGERNATURE
DOI: 10.1007/s12011-020-02490-4
关键词
K2Cr2O7; Heavy metals; Genotoxicity; Fish; Hematological parameters; DNA
资金
- NATP-II, Bangladesh Agricultural Research Council [CRG-364]
- Ministry of Education of Bangladesh [2017/503/MoE]
The research indicated that hexavalent chromium has significant effects on hematological, histopathological, and genetic changes in striped catfish. The study demonstrated that striped catfish is sensitive to chromium and can serve as a bio-indicator for assessing aquatic metal pollution.
Heavy metal pollution due to anthropogenic activities poses a great threat to aquatic organisms. The present study was conducted to evaluate the cytotoxic and genotoxic effects of hexavalent chromium (potassium dichromate) on hemato-biochemical, histo-pathological, and genetical changes in striped catfish Pangasianodon hypophthalmus. Three sub-lethal doses (0.8, 1.6, and 3.2 mg/L) of chromium (Cr) were selected and fish were exposed in vivo contrasting with a control (0 mg/L) for 30 days. The study revealed that various hemato-biochemical parameters showed a significant decrease in hemoglobin (Hb), red blood cells (RBCs), and blood glucose content, whereas white blood cells (WBCs) significantly increased in Cr exposed fish. Frequencies of all forms of structural abnormalities of erythrocytes (erythrocytic cellular abnormalities; ECA, erythrocytic nuclear abnormalities; ENA and erythroblasts; Ebs) were significantly increased in higher two test concentrations (1.6 and 3.2 mg/L) when compared to control. Differential leucocyte count exhibited significant increase in neutrophil and decrease in lymphocytes in the highest Cr treated group. The severity of various histo-pathological changes in the gills, liver, and kidney were increased considerably with the increase of Cr concentrations. Similarly, the amount of DNA (ng/mu l) decreased significantly in blood and tissues of different vital organs where the liver showed the highest decline compared to control in a concentration-dependent manner. Taken altogether, P. hypophthalmus is susceptible to Cr and can be used as a bio-indicator to assess aquatic metal pollution.
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