期刊
BIOLOGICAL REVIEWS
卷 96, 期 3, 页码 961-975出版社
WILEY
DOI: 10.1111/brv.12686
关键词
calpain; CAPN; CAPNS1; calpastatin; CAST; cancer
类别
资金
- National Natural Science Foundation of China [81970793]
- Tianjin Clinical Key Discipline Project [TJLCZDXKT003]
The calpain system plays crucial roles in cancer progression by mediating the proteolysis of specific substrates and regulating important signaling molecules. mu-calpain, m-calpain, and calpastatin are the three molecules initially identified as components of the calpain system, with roles in cancer progression through regulation of cellular processes and potential as targets for anti-cancer interventions.
The calpain system is required by many important physiological processes, including the cell cycle, cytoskeleton remodelling, cellular proliferation, migration, cancer cell invasion, metastasis, survival, autophagy, apoptosis and signalling, as well as the pathogenesis of a wide range of disorders, in which it may function to promote tumorigenesis. Calpains are intracellular conserved calcium-activated neutral cysteine proteinases that are involved in mediating cancer progression via catalysing and regulating the proteolysis of their specific substrates, which are important signalling molecules during cancer progression. mu-calpain, m-calpain, and their specific inhibitor calpastatin are the three molecules originally identified as comprising the calpain system and they contain several crucial domains, specific motifs, and functional sites. A large amount of data supports the roles of the calpain-calpastatin system in cancer progression via regulation of cellular adhesion, proliferation, invasion, metastasis, and cellular survival and death, as well as inflammation and angiogenesis during tumorigenesis, implying that the inhibition of calpain activity may be a potential anti-cancer intervention strategy targeting cancer cell survival, invasion and chemotherapy resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据