期刊
BIOFOULING
卷 36, 期 9, 页码 1129-1148出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2020.1859499
关键词
Bacteria; Fungi; biofilm; in vitro; microcosms; ex vivo
资金
- Cearense Foundation for the Support of Scientific and Technological Development (FUNCAP)
- National Council for Scientific and Technological Development (CNPq
- Brazil) [436382/2018-0]
Microbial biofilms are a natural adaptation of microorganisms, typically composed of multiple microbial species, exhibiting complex community organization and cooperation. Biofilm dynamics and their complex architecture are challenging for basic analyses, including the number of viable cells, biomass accumulation, biofilm morphology, among others. The methods used to study biofilms range from in vitro techniques to complex in vivo models. However, animal welfare has become a major concern, not only in society, but also in the academic and scientific field. Thus, the pursuit for alternatives to in vivo biofilm analyses presenting characteristics that mimic in vivo conditions has become essential. In this context, the present review proposes to provide an overview of strategies to study biofilms of medical interest, with emphasis on alternatives that approximate experimental conditions to host-associated environments, such as the use of medical devices as substrata for biofilm formation, microcosm and ex vivo models.
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