Electrochemical dual signal sensing platform for the simultaneous determination of dopamine, uric acid and glucose based on copper and cerium bimetallic carbon nanocomposites

A highly sensitive electrochemical sensor for the simultaneous dual signal determination of dopamine (DA), uric acid (UA) and glucose (Glu) has been obtained using nanocomposites based on the copper and cerium bimetallic nanoparticles and carbon nanomaterials of graphene and single-walled carbon nanotubes in the presence of Tween 20 (GR-SWCNT-Ce-Cu-Tween 20) modified glassy carbon electrode. The surface morphology of the nanocomposites was characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD), and the electrochemical behavior of the sensor was investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) with potassium ferricyanide as probe. In the coexistence system of DA, UA and Glu, three clear and well-isolated voltammetric peaks were obtained by CV and differential pulse voltammetry (DPV), and oxidation peak currents of DA and UA are positively correlated with their concentrations respectively, while the peak current of Glu is negatively correlated with its concentration. Linearity was obtained in the ranges of 0.1-100 mu M for dopamine, 0.08-100 mu M for uric acid and 1-1000 mu M for glucose with DPV, and the detection limits (S/ N = 3) of 0.0072 mu M, 0.0063 mu M, and 0.095 mu M for DA, UA and Glu, respectively. The method was successfully applied to the determination of DA, UA and Glu in blood serum samples, which provided a reference for further sensor research. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

A highly sensitive electrochemical sensor has been developed for the simultaneous dual signal determination of dopamine, uric acid and glucose. The sensor shows clear voltammetric peaks for each analyte and has good linearity and low detection limits.