期刊
BIOCONJUGATE CHEMISTRY
卷 32, 期 1, 页码 106-110出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.0c00706
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资金
- National Key R&D Program of China [2017YFA0205901]
- NSFC [21675036, 51873046, 51903064, 21874033]
- CAS Pioneer Hundred Talents Program
- CAS Key Research Program of Frontier Sciences [ZDBS-LY-SLH039]
- Beijing Natural Science Foundation [7204286]
- China Postdoctoral Science Foundation [2019T120074]
A redox supramolecular assembly (ROSA) system targeting HIV Gag protein was designed to trap HIV and control the virus, providing a potential anti-HIV strategy.
For HIV/AIDS treatment, the cocktail therapy which uses a combination of anti-retroviral drugs remains the most widely accepted practice. However, the potential drug toxicity, patient tolerability, and emerging drug resistance have limited its long-term efficiency. Here, we design a HIV Gag protein-targeting redox supramolecular assembly (ROSA) system for potential HIV inhibition. An assembling precursor was constructed through conjugation of an oxidation-activatable fluorogenic compound BQA with a selected tetrapeptide GGFF. Since BQA shares a similar structure with the known Gag inhibitor, the precursor could bind to HIV Gag protein with moderate affinity. Moreover, after oxidation, the corresponding nanofibers could bind to Gag protein and trap HIV to realize virus control, thus providing a potential anti-HIV strategy.
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