4.6 Review

Targeting protein tyrosine kinase 6 in cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression

Darshan S. Chandrashekar et al.

ONCOGENE (2020)

Review Biochemistry & Molecular Biology

Structure, Function, and Regulation of the SRMS Tyrosine Kinase

Chakia J. McClendon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

PSPC1: a contextual determinant of tumor progression

Yaw-Dong Lang et al.

MOLECULAR & CELLULAR ONCOLOGY (2020)

Article Oncology

Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor Cells

Darren J. Wozniak et al.

MOLECULAR CANCER THERAPEUTICS (2019)

Article Biochemistry & Molecular Biology

COSMIC: the Catalogue Of Somatic Mutations In Cancer

John G. Tate et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Oncology

Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome

Cecilie Bucher-Johannessen et al.

CLINICAL EPIGENETICS (2019)

Article Biochemistry & Molecular Biology

Clustal Omega for making accurate alignments of many protein sequences

Fabian Sievers et al.

PROTEIN SCIENCE (2018)

Article Biochemistry & Molecular Biology

Decreased expression of protein tyrosine kinase 6 contributes to tumor progression and metastasis in laryngeal squamous cell carcinoma

Di Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Mathematical & Computational Biology

Ensembl variation resources

Sarah E. Hunt et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2018)

Article Biochemical Research Methods

Deep Phosphotyrosine Proteomics by Optimization of Phosphotyrosine Enrichment and MS/MS Parameters

Yuichi Abe et al.

JOURNAL OF PROTEOME RESEARCH (2017)

Article Biochemistry & Molecular Biology

PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and Migration Through Phosphorylation of Eps8

Won-Sik Shin et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Article Multidisciplinary Sciences

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer

Darren J. Wozniak et al.

NATURE COMMUNICATIONS (2017)

Article Oncology

Overexpression of PTK6 predicts poor prognosis in bladder cancer patients

Xue-lian Xu et al.

JOURNAL OF CANCER (2017)

Article Biochemistry & Molecular Biology

Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution

Manish Kumar Thakur et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution

Manish Kumar Thakur et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Oncology

Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer

Priya S. Mathur et al.

MOLECULAR CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins

Mi-Jeong Park et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Ippei Kikuchi et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Protein tyrosine kinase 6 mediates TNFα-induced endothelial barrier dysfunction

R. J. Haines et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Pharmacology & Pharmacy

Novel 4-anilino-α-carboline derivatives induce cell death in nonadhesive breast cancer cells through inhibition of Brk activity

Markus Oelze et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

Gaofeng Fan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Dermatology

Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin

Michael I. Chastkofsky et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Review Dermatology

miR-214 as a Key Hub that Controls Cancer Networks: Small Player, Multiple Functions

Elisa Penna et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Chemistry, Medicinal

Discovery of 4-anilino α-carbolines as novel Brk inhibitors

Kazem Ahmed Mahmoud et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Chemistry, Medicinal

Discovery of (E)-5-(benzylideneamino)-1H-benzo[d]imidazol-2(3H)-one derivatives as inhibitors for PTK6

Hyun Jae Shim et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Review Medicine, General & Internal

Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer

Yu Zheng et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Medicine, Research & Experimental

Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma

Xue-Kui Liu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Biochemistry & Molecular Biology

Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers

Nancy L. Cho et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells

Shin-Ae Kang et al.

BIOCHEMICAL JOURNAL (2012)

Article Oncology

Targeting Protein Tyrosine Kinase 6 Enhances Apoptosis of Colon Cancer Cells following DNA Damage

Jessica J. Gierut et al.

MOLECULAR CANCER THERAPEUTICS (2012)

Article Oncology

Mechanisms of HGF/Met Signaling to Brk and Sam68 in Breast Cancer Progression

Alessia Locatelli et al.

HORMONES & CANCER (2012)

Article Chemistry, Medicinal

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors

Hongbo Zeng et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Biochemistry & Molecular Biology

X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

Jodi Muckelbauer et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2011)

Article Biotechnology & Applied Microbiology

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

Theonie Anastassiadis et al.

NATURE BIOTECHNOLOGY (2011)

Article Pharmacology & Pharmacy

Brk/PTK6 signaling in normal and cancer cell models

Julie H. Ostrander et al.

CURRENT OPINION IN PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Interactions of STAP-2 with Brk and STAT3 Participate in Cell Growth of Human Breast Cancer Cells

Osamu Ikeda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

Identification of β-catenin as a target of the intracellular tyrosine kinase PTK6

Helena L. Palka-Hamblin et al.

JOURNAL OF CELL SCIENCE (2010)

Article Biochemical Research Methods

Comparative Analysis of Human Src-Family Kinase Substrate Specificity in Vitro

Hiroyuki Takeda et al.

JOURNAL OF PROTEOME RESEARCH (2010)

Article Biochemistry & Molecular Biology

Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor

Yu Zheng et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

Jiannong Li et al.

NATURE CHEMICAL BIOLOGY (2010)

Article Multidisciplinary Sciences

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival

Hanna Y. Irie et al.

PLOS ONE (2010)

Article Pathology

Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage

Amanda J. Harvey et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

Article Biochemistry & Molecular Biology

Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6

Sunggeon Ko et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

Osamu Ikeda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemical Research Methods

Jalview Version 2-a multiple sequence alignment editor and analysis workbench

Andrew M. Waterhouse et al.

BIOINFORMATICS (2009)

Letter Cell Biology

DOG 1.0: illustrator of protein domain structures

Jian Ren et al.

CELL RESEARCH (2009)

Article Cell Biology

BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

Kiven E. Lukong et al.

CELLULAR SIGNALLING (2009)

Article Cell Biology

Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration

Kiven E. Lukong et al.

CELLULAR SIGNALLING (2008)

Article Gastroenterology & Hepatology

Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitro

Robert H. Whitehead et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2008)

Article Biochemistry & Molecular Biology

Gene expansion and retention leads to a diverse tyrosine kinase superfamily in amphioxus

Salvatore D'Aniello et al.

MOLECULAR BIOLOGY AND EVOLUTION (2008)

Article Biochemistry & Molecular Biology

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Mohammad Azam et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

Bin Xiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Oncology

The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovary

Rosemarie E. Schmandt et al.

CANCER BIOLOGY & THERAPY (2006)

Article Biochemistry & Molecular Biology

Identification of STAT3 as a specific substrate of breast tumor kinase

L. Liu et al.

ONCOGENE (2006)

Article Biochemistry & Molecular Biology

Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine

Andrea Haegebarth et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Pathology

Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes

M Kasprzycka et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

Article Biochemistry & Molecular Biology

Tyrosine phosphorylation of Sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

KE Lukong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Interaction between Brk kinase and insulin receptor substrate-4

HQ Qiu et al.

ONCOGENE (2005)

Article Dermatology

Role of breast tumour kinase in the in vitro differentiation of HaCaT cells

TC Wang et al.

BRITISH JOURNAL OF DERMATOLOGY (2005)

Article Biochemistry & Molecular Biology

Role of the Brk SH3 domain in substrate recognition

HQ Qiu et al.

ONCOGENE (2004)

Article Otorhinolaryngology

Identification of tyrosine kinases overexpressed in head and neck cancer

HS Lin et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2004)

Article Biochemistry & Molecular Biology

Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain

EM Hong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Brk activates Rac1 and promotes cell migration and invasion by phosphorylating paxillin

HY Chen et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition

HQ Qiu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Characterization of the 5′-flanking region of the human PTK6 gene

KN Kang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2002)

Article Biochemistry & Molecular Biology

Letter to the Editor:: Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain

EM Hong et al.

JOURNAL OF BIOMOLECULAR NMR (2001)

Article Biochemistry & Molecular Biology

A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK

PJ Mitchell et al.

ONCOGENE (2000)

Article Biochemistry & Molecular Biology

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

JJ Derry et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)