期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1875, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2020.188463
关键词
Extracellular vesicles; Exosomes; PD-1/PD-L1; Liquid biopsy; Cancer; Immune-checkpoint inhibitors
资金
- MIUR, Italy (PRIN 2017) [2017NR7W5K]
Monoclonal antibodies targeting the PD-1/PD-L1 axis enhance immune response to cancer, but some patients do not benefit from treatment due to resistance or adverse reactions. Currently, PD-L1 expression in tumor tissues is used to predict drug response, but researchers are interested in identifying blood-based biomarkers for dynamic monitoring of response.
Monoclonal antibodies that inhibit the programmed cell death protein 1 axis (anti-PD-1/PD-L1) are part of a new pharmacological strategy aimed at reinforcing the immune response to cancer. Despite the success in several cancer types, a significant percentage of patients do not benefit from treatment with these drugs due to intrinsic or acquired resistance or the occurrence of immune-related adverse reactions. Assessment of PD-L1 expression in tumor tissues is currently used to predict drug response in the clinics; however, there is a growing interest in identifying blood-based biomarkers that, owing to the minimally-invasive nature, can allow a dynamic monitoring of drug response in daily clinical practice. In the current review article, we discuss whether the assessment of PD-L1 mRNA and protein levels in circulating extracellular vesicles may have the potential to predict the likelihood of tumor response to anti-PD-1/PD-L1 antibodies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据