期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1867, 期 7, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2020.166066
关键词
E3 ubiquitin ligases; RNA-binding proteins; NHL domain; miRNA regulation; Neurodevelopment; Pathophysiology
资金
- Department of Biotechnology (DBT) [BT/PR20692/BRB/10/1538/2016]
- DST-SERB [CRG/2019/000316]
TRIM-NHL proteins possess unique RNA binding ability and E3 ligase activity, playing crucial roles in cellular processes and potential involvement in various pathological conditions.
TRIM proteins are RING domain-containing modular ubiquitin ligases, unique due to their stimuli specific expression, localization, and turnover. The TRIM family consists of more than 76 proteins, including the TRIMNHL sub-family which possesses RNA binding ability along with the inherent E3 Ligase activity, hence can be classified as a unique class of RNA Binding Ubiquitin Ligases (RBULs). Having these two abilities, TRIM-NHL proteins can play important role in a wide variety of cellular processes and their dysregulation can lead to complex and systemic pathological conditions. Increasing evidence suggests that TRIM-NHL proteins regulate RNA at the transcriptional and post-transcriptional level having implications in differentiation, development, and many pathological conditions. This review explores the evolving role of TRIM-NHL proteins as TRIM-RBULs, their ubiquitin ligase and RNA binding ability regulating cellular processes, and their possible role in different pathophysiological conditions.
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