期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1865, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbagen.2020.129776
关键词
Arginine methylation; Protein arginine methyltransferase 1 (PRMT1); Central nervous system (CNS)
资金
- JSPS KAKENHI [17H06730, 20K15913, 17H01519]
- JSPS Leading Initiative for Excellent Young Researchers (LEADER)
- Gifu University Yoshizaki Research Support Fund (YRSF)
- Inamori Foundation Research Grants
- Mitsubishi Foundation
- Grants-in-Aid for Scientific Research [20K15913, 17H06730, 17H01519] Funding Source: KAKEN
PRMT1 is crucial for the development of neurons, astrocytes, and oligodendrocytes, requiring further investigation. The relevance of PRMT1 in neurodegenerative diseases will continue to be a hot topic.
Background: Protein arginine methyltransferase 1 (PRMT1), a major type I arginine methyltransferase in mammals, methylates histone and non-histone proteins to regulate various cellular functions such as transcription, DNA damage response, and signal transduction. Scope of review: This review summarizes previous and recent studies on PRMT1 functions in major cell types of the central nervous system. We also discuss the potential involvement of PRMT1 in neumdegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia. Also, we raise key questions that must be addressed in the future to more precisely understand the roles of PRMT1. Major conclusions: Recent studies revealed that PRMT1 is essential for the development of neurons, astrocytes, and oligodendrocytes, although further investigation using cell type-specific PRMT1-deficient animals is required. In addition, the relevance of PRMT1 in neurodegenerative diseases will continue to be a hot topic. General significance: PRMT1 is important for neural development and neurodegenerative diseases.
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