期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 49, 期 1, 页码 203-215出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20200425
关键词
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资金
- Dutch Research Council (NWO)
Natural peptide products are valuable sources of important therapeutic agents. By understanding the structure-activity relationships and biosynthetic machineries, it is possible to create novel products with improved pharmacological properties to combat antimicrobial resistance.
Natural peptide products are a valuable source of important therapeutic agents, including antibiotics, antivirals and crop protection agents. Aided by an increased understanding of structure-activity relationships of these complex molecules and the biosynthetic machineries that produce them, it has become possible to re-engineer complete machineries and biosynthetic pathways to create novel products with improved pharmacological properties or modified structures to combat antimicrobial resistance. In this review, we will address the progress that has been made using non-ribosomally produced peptides and ribosomally synthesized and post-translationally modified peptides as scaffolds for designed biosynthetic pathways or combinatorial synthesis for the creation of novel peptide antimicrobials.
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