期刊
BIOCHEMICAL PHARMACOLOGY
卷 187, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2021.114405
关键词
Infectious diseases; Phagocytosis; NLRP3 inflammasome
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico do Brasil - CNPq [306839/2019-9]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro - FAPERJ [E-26/202.701/2019, E-26/010.002260/2019, 26/010.101036/2018, E-26/202.774/2018]
Purinergic signalling is a conserved pathway mediated by extracellular nucleotides and nucleosides, activating host innate immune defense mechanisms during intracellular pathogen infections.
Purinergic signalling is an evolutionarily conserved signalling pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides released from host cells during intracellular pathogen infections activate plasma membrane purinergic type 2 receptors (P2 receptors) that stimulate microbicidal mechanisms in host innate immune cells. P2X ion channels and P2Y G protein-coupled receptors are involved in activating host innate immune defence mechanisms, phagocytosis, phagolysosomal fusion, production of reactive species, acidification of parasitophorous vacuoles, inflammasome activation, and the release of cytokines, chemokines, and other inflammatory mediators. In this review, as part of a special issue in tribute to Geoffrey Burnstock, we discuss advances in understanding the importance of P2 receptors in the host antimicrobial innate mechanisms against intracellular pathogen infections.
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