期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 35, 期 3, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2021.101484
关键词
diabetic kidney disease; chronic kidney disease; microbiota; metabolites; inflammation
资金
- Top Consortia for Knowledge and Innovation (TKI-PPP) grant (Health-Holland, 2020)
Diabetic kidney disease is a growing burden on public health and the leading cause of end-stage kidney diseases. Interactions between host-gut microbiota have emerged as essential for maintaining host homeostasis, particularly evident in the bidirectional microbiota-kidney crosstalk during progressive kidney dysfunction, leading to a vicious cycle of dysbiosis and renal dysfunction.
Diabetic kidney disease (DKD) represents a growing public health burden and is the leading cause of end-stage kidney diseases. In recent years, host-gut microbiota interactions have emerged as an integral part for host homeostasis. In the context of nephropathies, mounting evidence supports a bidirectional microbiota-kidney crosstalk, which becomes particularly manifest during progressive kidney dysfunction. Indeed, in chronic kidney disease (CKD), the healthy microbiota structure is disrupted and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened. In this review, we will summarize the evidence from clinical/experimental studies concerning the occurrence of gut dysbiosis in diabetic and non -diabetic CKD, discuss the functional consequences of dysbiosis for CKD progression and debate putative therapeutic interventions targeting the intestinal microbiome. (c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据