期刊
BEHAVIOURAL BRAIN RESEARCH
卷 396, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2020.112876
关键词
Mapk; Maternal immune activation; Schizophrenia; Prepulse inhibition; Contingency learning; Rat
This study used the maternal immune activation rat model to investigate the role of MAPK in sensorimotor gating and adaptive learning deficits in schizophrenia. The findings showed a negative correlation between MAPK expression and PPI exclusively in MIA rats, suggesting a modulatory role for MAPK in sensorimotor gating pathology. Additionally, the correlation between MAPK and adaptive learning capacity observed in control rats was absent in rats exposed to MIA.
Dysfunction within the mitogen-activated protein kinase (MAPK) cascade has been recognised as a pathological feature of schizophrenia, however the possible mechanistic connection to the disease phenotype remains unexplored. Using the maternal immune activation (MIA) rat model of schizophrenia, the present study investigated the involvement of prefrontal cortex (PFC) MAPK in sensorimotor gating and adaptive learning deficits via western blot, pre-pulse inhibition (PPI) testing, and a contingency degradation operant task, respectively. Principle findings identified a negative relationship between basal MAPK expression and PPI exclusively in MIA rats, suggesting a modulatory role for MAPK in sensorimotor gating pathology. In addition, the correlation between MAPK and adaptive learning capacity observed in control rats was absent for rats exposed to MIA. Findings are considered with respect to the glutamatergic NMDA hypofunction theory of schizophrenia, as well as the critical role of PFC in contingency learning.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据