期刊
BEHAVIORAL AND BRAIN FUNCTIONS
卷 16, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12993-020-00172-8
关键词
Vascular dementia; Cognition function; Anti-inflammation; Anti-oxidant; Astaxanthin
资金
- University-level Research Project [ZPCSR2017009, ZPCSR2017006]
- Xinmiao Talent Project of Zhejiang Province [2017R435007]
- General Scientific Research Project of Zhejiang Education Department [Y201738540]
- Municipal Natural Science Foundation of Ningbo [202003N4336, 2019A610289]
- NATCM TCM Inheritance and Innovation Hundred-Thousand-Ten Thousand Talents Project (QiHuang Scholar)-National TCM Leading Personnel Support Program (NATCM Personnel and Education Department [2018]) [12]
- Cultivation Project of National Natural Science Foundation [XY20-06]
Objective The purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice. Method VD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST was intragastrically administered for 30 days. Object recognition test and morris water maze test were used to evaluate cognitive function. Hematoxylin and eosin staining was performed to observe the hippocampal neuron structure. Enzyme-linked immunosorbent assay kit and bicinchoninic acid kit were respectively adopted to measure IL-1 beta and IL-4 protein expression and superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in hippocampus and prefrontal cortex. Results AST improved the discrimination ability of VD mice. The escape latency and path length of VD mice treated with AST were dramatically reduced. Besides, AST 200 mg/kg enhanced crossing platform time and the number of times crossing the platform quadrant, and alleviated the morphological impairment in VD mice. Moreover, we found that AST inhibited IL-1 beta expression and MDA content, whereas promoted IL-4 expression and SOD activity in a dose-dependent manner. Conclusion AST could improve cognitive impairment and hippocampal neurons in VD mice, which may be related to suppression of inflammatory response and oxidative stress.
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