期刊
ARCHIVES OF ORAL BIOLOGY
卷 124, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2020.104955
关键词
Matrix metalloproteinase 8; Gingival crevicular fluid; Chair-side test; Periodontal diseases
资金
- Helsinki University Hospital Research Foundation [TYH2016251, TYH207251, TYH 2018229, Y1014SLO17, Y1014SLO18]
- Apollonia Foundation, Helsinki, Finland
- Karolinska Institute, Stockholm, Sweden
The study examined the potential of salivary aMMP-8 level testing as a diagnostic tool for periodontal disease at different stages, with higher levels found in the P-IV group compared to others, and significantly higher levels in the P-III and gingivitis groups compared to the healthy group.
Objective: There is a need for a reliable complementary diagnostic tool that ideally helps to screen, differentiate sites, activities of and predict future periodontal tissue destruction. The purpose of this cross-sectional study was to investigate the screening and prevention potential of the chair-side/point-of-care (PoC) diagnostic test of salivary active matrix metalloproteinase-8 (aMMP-8) levels at different stages of periodontal disease and periodontal health. Material & methods: 80 individuals were included in this study; 18 with periodontitis stage 3 (P-Stage III), 19 with periodontitis stage-4 (P-Stage IV), 21 with gingivitis, and 22 with clinically healthy periodontium (H). The aMMP-8 levels in GCF and saliva were analyzed by chairside point-of-care aMMP-8 lateral flow immunotest and also by a time-resolved immunofluorescence assay (IFMA). Results: The sensitivity of the chair-side/PoC test was 83.9 % while specificity was 79.2 %. The aMMP-8 IFMA levels in GCF were significantly higher in P-Stage IV group than P-Stage III, gingivitis and healthy groups (p = 0.01, p = 0.001, p = 0.00, respectively). Moreover, P-Stage III and gingivitis groups had significantly higher aMMP-8 IFMA levels than the healthy group (p < 0.05). Conclusion: The aMMP-8 chair-side test showed promising results in its ability to recognize and predict the inflammatory status even at the very initial/early stages. aMMP-8 chair-side test could be a valuable adjunctive diagnostic and preventive tool to conventional clinical methods in detecting periodontal disease.
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