期刊
DALTON TRANSACTIONS
卷 45, 期 28, 页码 11540-11553出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6dt01795a
关键词
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资金
- Department of Science and Technology
- Department of Biotechnology, Government of India, New Delhi
A novel, quinoline-based smart probe L has been designed for the detection of Al3+ and Cu2+ at physiological range. The unprecedented solvent-dependent sensitivities of the probe L for simultaneous detection of Al3+ and Cu2+ ions with high selectivity and sensitivity have been observed for the first time. It displays quick responses through visible colorimetric as well as fluorogenic changes towards both Al3+ and Cu2+, as delineated by absorption and fluorescence titrations. The sensitivity of the fluorescence-based assay (12.6 nM) for Al3+ and (18.4 nM) fo(r) Cu2+ is far below the limit recommended in the World Health Organization (WHO) guidelines for drinking water. From H-1 NMR data, the Job plot and the ESI-MS spectrum, 1 : 2 stoichiometric complexations between L and both metals have been established. The geometry and spectral property of L and its metal complexes have been well rationalized by DFT calculations. This probe L has been tested as being highly suitable for mapping Al3+ and Cu2+ in human breast cancer cells, MCF7, thus providing a wonderful candidate for tracking Al3+ and Cu2+ in biological organisms and processes. The proposed chemosensor L has also been successfully applied for analysis of real samples.
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