期刊
APPLIED SURFACE SCIENCE
卷 535, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2020.147675
关键词
Silver; Polytetrafluoroethylene; Biofilm; Antibacterial activity; Corrosion
类别
资金
- UK Engineering and Physical Sciences Research Council [EP/P00301X/1]
- EPSRC [EP/P00301X/1] Funding Source: UKRI
A silver nanoparticle/polytetrafluorethylene (AgNP/PTFE) coating for metallic implants was fabricated to enhance antibacterial and corrosion resistance properties, demonstrating sustained release of silver ions to inhibit bacterial growth. The anti-adhesion mechanism was explained using DLVO and XDLVO theories, offering potential for preventing implant-associated infections.
In this research, a silver nanoparticle/polytetrafluorethylene (AgNP/PTFE) coating for metallic implants was fabricated using a facile layer-by-layer coating method. PTFE nanoparticles were immobilized in a sol-gel matrix and dip-coated onto 316L stainless steel via a mussel-inspired approach followed by AgNP deposition. Benefiting from the synergistic effect of antibacterial AgNP and non-stick PTFE, the AgNP/PTFE coating exhibited superior antibiofilm activity against Escherichia coli WT F1693 and enhanced corrosion resistance. Compared with surfaces only coated with PTFE, the AgNP/PTFE coated surfaces were capable of sustained release of silver ions, inhibiting up to similar to 50% bacterial biomass accumulation after 7 days. To understand the anti-adhesion mechanism, both classic DLVO and XDLVO theories were used to model and explain bacterial adhesion. Despite concerns that an over-release of silver ions may cause toxic effects towards mammalian cells, the coating procedures offered ease of control over the silver loading, making it potentially useful for preventing metallic implant-associated infections.
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