期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 105, 期 2, 页码 503-508出版社
SPRINGER
DOI: 10.1007/s00253-020-11062-4
关键词
Leprosy; Tuberculosis; Skin; T cell; Diagnosis
资金
- US Department of Health and Human Services Health Resources and Services Administration (HRSA) [AAI15006]
- NIAID [AAI15006]
- American LeprosyMissions
- NIH SBIR [HHSN272201800019C]
Despite the widespread use of tuberculin skin testing (TST), the lack of specificity and supply issues remain limitations. Advances in modern technologies have been discussed for improving mycobacterial skin testing, with potential benefits for diagnostic strategies for other infections.
Immunological and molecular advances have modernized diagnostic testing for many diseases. Although interferon gamma-release and polymerase chain reaction assays have been developed to detect Mycobacterium tuberculosis (Mtb) infection, purified protein derivative (PPD)-based tuberculin skin testing (TST) remains the most widely used method. Indeed, the TST is a simple and cost-effective tool that can be easily applied for widespread screening for Mtb infection. However, the lack of specificity has been a limitation of these tests, and, more recently, supply issues have arisen. Building upon the skin tests that historically have been used within TB and leprosy control programs, we discuss recent developments using modern technologies for improving mycobacterial skin testing as well as practical advantages inherent to the technique. Furthermore, we outline how this knowledge could be applied to develop similar tests that could benefit diagnostic strategies for other infections.
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