期刊
ANTICANCER RESEARCH
卷 41, 期 1, 页码 379-384出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.14786
关键词
Survival score; glioblastoma multiforme; radiotherapy; treatment personalization
类别
A new survival score was developed for GBM patients receiving radiotherapy, based on factors like performance status, upfront resection, MGMT promoter methylation, and unifocal GBM. This score was significantly associated with patient survival rates, enabling improved treatment personalization.
Background/Aim: In a previous study investigating radiotherapy for newly diagnosed glioblastoma multiforme (GBM), significant or almost significant associations with survival were found for performance status, upfront resection, 0 6 -methylguanine-DNA methyl-transferase (MGMT) promoter methylation and unifocal GBM. This study aimed to create a survival score based on these factors. Patients and Methods: Most of the 81 patients included received resection of GBM followed by radiochemotherapy (59.4 Gy/33 or 60 Gy/30 fractions). The previously identified predictors of survival were re-evaluated. Factors significantly associated with survival were used for the score. Results: All factors were significantly associated with survival. For each factor, 0 points (less f avorable survival) or 1 point (more favorable survival) were assigned and added for each patient. Three groups were designed, 0-1 (n=10), 2 (n=21) and 3-4 points (n=50); 12-month survival rates were 0%, 38% and 78% (p<0.001). Conclusion: A new survival score was created for patients requiring radiotherapy for GBM that can improve treatment personalization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据