期刊
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
卷 16, 期 -, 页码 277-298出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-031620-113409
关键词
complement; aging; neurodegeneration; Alzheimer's disease; vasculature
资金
- National Institutes of Health [R01 NS093652, R01 AG057509, R01 AG020670, RF1 AG054111, RF1 AG062257]
The classic innate immune signaling pathways play a crucial role in the immune response in the brain, despite their relative absence in this immune-privileged tissue. Studies over the past decade have linked complement protein production and activation to age-related functional changes and neurodegeneration. Reactivation of the complement signaling pathway in aging and disease has provided new insights into brain aging and neurological disease pathogenesis.
Classic innate immune signaling pathways provide most of the immune response in the brain. This response activates many of the canonical signaling mechanisms identified in peripheral immune cells, despite their relative absence in this immune-privileged tissue. Studies over the past decade have strongly linked complement protein production and activation to age-related functional changes and neurodegeneration. The reactivation of the complement signaling pathway in aging and disease has opened new avenues for understanding brain aging and neurological disease pathogenesis and has implicated cell types such as astrocytes, microglia, endothelial cells, oligodendrocytes, neurons, and even peripheral immune cells in these processes. In this review, we aim to unravel the past decade of research related to complement activation and its numerous consequences in aging and neurological disease.
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