期刊
DALTON TRANSACTIONS
卷 45, 期 16, 页码 6812-6815出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6dt00186f
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资金
- Technology Strategy Board, EPSRC
- Ministry of Education, Brunei Darussalam
- EPSRC [EP/K039202/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K039202/1] Funding Source: researchfish
Here in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2](2) dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2](2) dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action.
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