4.7 Article

Dietary nucleotide supplementation as an alternative to in-feed antibiotics in weaned piglets

期刊

ANIMAL
卷 15, 期 1, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.animal.2020.100021

关键词

Additive; Growth promoters; Gut health; Intestinal morphology; Swine

资金

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [403281/2016-4]
  3. Instituto Nacional de Ciencia Animal (INCT-CA)

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The study demonstrated that nucleotide supplementation had a similar effect to antibiotics on piglet performance and was superior in enhancing intestinal health. Nucleotides improved gut health by modulating local immune response and intestinal mucosa development, suggesting they may be an alternative to antibiotics as growth promoters.
Nucleotides are important to cell growth and division and are crucial to the rapid proliferation of such cells as the intestinal mucosa and immune cells. Accordingly, the nucleotide requirements of animals are high during periods of rapid growth and periods of stress like post-weaning period. Thus, nucleotide supplementation may be a possible alternative to in-feed antibiotics as growth promoter in this phase. The study aimed to evaluate dietary nucleotide supplementation as an alternative to in-feed antibiotics on performance and gut health of weaned piglets. Ninety-six 21-day-old piglets, weighing 7.44 +/- 0.65 kg, were allocated into 1 of 3 treatments (8 pens per treatment; 4 pigs per pen) in a 14-day trial. Dietary treatments consisted of control: corn-soybean mealbased diet; nucleotides: control 2 g/kg of a nutritional additive with purified nucleotides; and antibiotic: control + 0.8 g/kg of antibiotic growth promoter based on colistin and tylosin. Performance variables and fecal score were not affected (P> 0.05) by supplementing nudeotide or antibiotic. Nucleotides treatment had similar effect to antibiotic and superior to control (P < 0.05) on enhancing duodenum vill us height, jejunum crypt depth, and reduction of Paneth cellular area. Duodenum and ileum of animals supplemented with nucleotides or antibiotics had higher (P < 0.05) number of proliferating cells than did those of control animals, whereas the jejunum of animals that received antibiotic diets presented more (P < 0.05) proliferating cells than either the nucleotides or control animals. Jejunum of nucleotide-treated piglets showed a greater number of apoptotic cells than those fed antibiotic or control diets (P < 0.05). Nucleotides and antibiotic treatments decreased the B lymphocyte counts in duodenum and ileum (P < 0.05) but increased in the jejunum (P < 0.05), when compared to the control treatment. Relative abundance of mitogen-activated protein kinases-6, haptoglobin, and tumor necrosis factor-alpha mRNA was not influenced (P> 0.05) by treatments. In the Heal, antibiotic supplementation reduced total bacteria quantification compared to nucleotide supplementation or the control (P < 0.05), whereas nucleotides supplementation increased enterobacteria proliferation compared to the antibiotic or control diets (P< 0.05). However, nucleotides and antibiotic reduced (P < 0.05) colon total bacteria quantification when compared to control. These results suggest that the nucleotides source used to weaned piglets improved gut health by modulating the local immune response and modulating intestinal mucosa development, and, therefore, nucleotides may be an alternative to antibiotics as growth promoters. (C) 2020 The Authors. Published by Elsevier Inc. on behalf of The Animal Consortium.

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