期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 10, 页码 5230-5234出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202012877
关键词
amination; aryl halides; aryl radicals; nickel catalysis; nitroarenes
资金
- National Natural Science Foundation of China [21702130, 21871171]
- China Postdoctoral Science Foundation [2018M633452]
- 111 project [B14041]
This study demonstrates a photochemical C-N coupling of aryl halides with nitroarenes for the first time, catalyzed by a Ni-II complex in the absence of any external photosensitizer. The method provides a step-economic extension to the widely used Buchwald-Hartwig C-N coupling reaction and tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest the reaction proceeds via the addition of an aryl radical, generated from a Ni-I/Ni-III cycle, to a nitrosoarene intermediate.
A photochemical C-N coupling of aryl halides with nitroarenes is demonstrated for the first time. Catalyzed by a Ni-II complex in the absence of any external photosensitizer, readily available nitroarenes undergo coupling with a variety of aryl halides, providing a step-economic extension to the widely used Buchwald-Hartwig C-N coupling reaction. The method tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest that the reaction proceeds via the addition of an aryl radical, generated from a Ni-I/Ni-III cycle, to a nitrosoarene intermediate.
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