期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 9, 页码 4720-4731出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202013301
关键词
disease theranostics; nitric oxide; peroxynitrite; photoacoustic cavitation; photosensitization-free nanocapsules
资金
- Natural Science Foundation for Distinguished Young Scholars of Guangdong Province [2016A030306013]
- Science and Technology Program of Guangzhou [2019050001]
- Pearl River Young Talents Program of Science and Technology in Guangzhou [201906010047]
- National Key Research and Development Program of China [2018YFA0209800]
The study introduces a photosensitizer-free system that can achieve controlled release of NO in cancer cells, inducing apoptosis. Through photoacoustic technology, the release of nanocapsules and the production of highly cytotoxic peroxynitrite were achieved.
Photoacoustic (PA) technology can transform light energy into acoustic wave, which can be used for either imaging or therapy that depends on the power density of pulsed laser. Here, we report photosensitizer-free polymeric nanocapsules loaded with nitric oxide (NO) donors, namely NO-NCPs, formulated from NIR light-absorbable amphiphilic polymers and a NO-releasing donor, DETA NONOate. Controlled NO release and nanocapsule dissociation are achieved in acidic lysosomes of cancer cells. More importantly, upon pulsed laser irradiation, the PA cavitation can excite water to generate significant reactive oxygen species (ROS) such as superoxide radical (O-2(.-)), which further spontaneously reacts with the in situ released NO to burst highly cytotoxic peroxynitrite (ONOO-) in cancer cells. The resultant ONOO- generation greatly promotes mitochondrial damage and DNA fragmentation to initiate programmed cancer cell death. Apart from PA imaging, PA cavitation can intrinsically amplify reactive species via photosensitization-free materials for promising disease theranostics.
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